DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men.
- Author:
Yuan YANG
1
;
Cui-Ying XIAO
;
Zhou-Cun A
;
Si-Zhong ZHANG
;
Xiang LI
;
Si-Xiao ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; China; Chromosomes, Human, Y; genetics; Gene Deletion; Humans; Male; Oligospermia; genetics; Polymorphism, Restriction Fragment Length; RNA-Binding Proteins; genetics; Recombination, Genetic; genetics; Sequence Tagged Sites; Spermatogenesis; genetics
- From: Asian Journal of Andrology 2006;8(2):183-187
- CountryChina
- Language:English
-
Abstract:
AIMTo explore the possible effect of the deleted in azoospermia (DAZ) copy cluster deletion on spermatogenesis in the Chinese population, the deletion of the azoospermia factor c (AZFc) region was analyzed in 346 normozoospermic men.
METHODSThree DAZ single nucleotide variant loci and seven AZFc-specific sequence-tagged sites were examined with polymerase chain reaction (PCR)-restriction fragment length polymorphism and routine PCR.
RESULTSFive (1.4%) of the normozoospermic men were found to have deletion of gr/gr-DAZ1/DAZ2. None of the men were found to have b2/b4-entire DAZ deletion.
CONCLUSIONThe presence of gr/gr-DAZ1/DAZ2 deletion in five men with normozoospermia suggests that this deletion per se may not be sufficient for spermatogenic impairment in Chinese men.
