Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study.
- Author:
Luis A QUIÑONES
1
;
Carlos E IRARRÁZABAL
;
Claudio R ROJAS
;
Cristian E ORELLANA
;
Cristian ACEVEDO
;
Christian HUIDOBRO
;
Nelson E VARELA
;
Dante D CÁCERES
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Confidence Intervals; Cytochrome P-450 CYP1A1; genetics; Gene Amplification; Genes, p53; Genetic Variation; Genotype; Glutathione Transferase; genetics; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Prostatic Neoplasms; epidemiology; genetics; Risk Factors; Smoking
- From: Asian Journal of Andrology 2006;8(3):349-355
- CountryChina
- Language:English
-
Abstract:
AIMTo assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking.
METHODSIn a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk.
RESULTSThe joint risk for smokers carrying Pro* and M1*, Pro* and GSTM1null or GSTM1 null and CYP1A1 M1* variants was significantly higher (odds ratio [OR]: 13.13, 95% confidence interval [CI]: 2.41-71.36; OR: 3.97, 95% CI: 1.13-13.95 and OR: 6.87, 95% CI: 1.68-27.97, respectively) compared with that for the reference group, and for non-smokers was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group (OR: 8.87, 95% CI: 1.25-62.71).
CONCLUSIONOur results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.
