Modulatory effects of diallyl sulfide against testosterone- induced oxidative stress in Swiss albino mice.
- Author:
Sahdeo PRASAD
1
,
2
;
Neetu KALRA
;
Yogeshwer SHUKLA
Author Information
- Publication Type:Journal Article
- MeSH: Allyl Compounds; pharmacology; Animals; Catalase; metabolism; Glutathione Reductase; metabolism; Glutathione Transferase; metabolism; Lipid Peroxidation; drug effects; Liver; drug effects; Male; Mice; Oxidative Stress; drug effects; Prostate; drug effects; Sulfides; pharmacology; Superoxide Dismutase; metabolism; Testosterone; antagonists & inhibitors
- From: Asian Journal of Andrology 2006;8(6):719-723
- CountryChina
- Language:English
-
Abstract:
AIMTo investigate the protective effect of diallyl sulfide (DAS), a constituent of garlic, against testosterone-induced oxidative stress in male Swiss albino mice.
METHODSThe animals were given low (250 mg/animal) and high dose (500 mg/animal) of DAS in corn oil for 7 days along with testosterone (5 mg/kg body weight, i.p.). At the end of the study period, the prostate and the liver were dissected to determine various antioxidant enzyme levels (catalase, superoxide dismutase, glutathione reductase, glutathione-s-transferase) and lipid peroxidation.
RESULTSIn testosterone treated mice, depleted antioxidant enzyme level was accompanied with enhancement in lipid peroxidation in prostate and liver. DAS significantly restored the testosterone-induced antioxidant enzymes and lipid peroxidation in the both organs. These changes appear to be mediated by the antioxidant-enhancing effects of DAS.
CONCLUSIONThe results of the present study suggest that DAS is effective in exerting antioxidant effects by inhibiting testosterone-induced oxidative stress and might be helpful in preventing prostate cancer.
