Studies of heat shock protein 60 and heat shock protein 70 in oral lichen planus.
- Author:
Ping DI
1
;
Yan GAO
Author Information
- Publication Type:Journal Article
- MeSH: Chaperonin 60; biosynthesis; genetics; HSP70 Heat-Shock Proteins; biosynthesis; genetics; Humans; Lichen Planus, Oral; metabolism; pathology; Mouth Mucosa; metabolism; RNA, Messenger; biosynthesis
- From: Chinese Journal of Stomatology 2003;38(4):275-278
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the role of heat shock protein (HSP) 60 and HSP70 in the pathogenesis of oral lichen planus (OLP).
METHODSThe immunohistochemical SP methods were used to detected the expression of HSP60 and HSP70 in 62 cases of oral lichen planus, 10 cases of normal oral mucosa, 21 cases of chronic discoid lupus erythematosus (DLE), 10 cases of benign lymphoadenosis of mucosa, 46 cases of leukoplakia. RT-PCR was used to evaluate the expression of HSP60 mRNA and HSP70 mRNA in 12 cases of OLP and 5 cases of normal oral mucosa.
RESULTSHSP60 was expressed at much higher levels in OLP than other groups. The expression of HSP70 decreased in epithelial cells in erosive lichen planus group. HSP60 mRNA and HSP70 mRNA were expressed at high level in OLP.
CONCLUSIONHSP60 and HSP70 play an important role in pathogenesis of OLP.
