The effect of periodontal initial therapy on circulating TNF-alpha and HbA1C in type 2 diabetes patients with periodontitis.
- Author:
Pi-shan YANG
1
;
Yan WANG
;
Xiang-min QI
;
Jian-min REN
;
Shao-hua GE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Body Mass Index; Diabetes Mellitus, Type 2; blood; Female; Glycated Hemoglobin A; analysis; Humans; Lipids; blood; Male; Middle Aged; Periodontitis; blood; therapy; Tumor Necrosis Factor-alpha; analysis
- From:Chinese Journal of Stomatology 2003;38(5):364-366
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect and mechanism of periodontal initial therapy on type 2 diabetes patients with periodontitis.
METHODS15 type 2 diabetes patients with periodontitis were selected. Their body mass index (BMI), sulcus bleeding index (SBI), probing depth (PD), circulating tumor necrosis factor-alpha (TNF-alpha) concentration, and the value of glycosylated hemoglobin (HbA1C), triglycerides (TG) and cholesterol (CHOL) were assessed respectively before and 4-6 weeks after periodontal initial therapy.
RESULTSAfter initial therapy, SBI, PD, circulating TNF-alpha concentration, and the value of HbA1C and TG were reduced significantly (P<0.05), while there were no significant differences in BMI and CHOL value (P>0.05).
CONCLUSIONSPeriodontal initial therapy can effectively reduce HbA1C value in type 2 diabetes patients with periodontitis, possibly through the reduction of circulating TNF-alpha concentration.
