The association between interleukin-1 receptor antagonist genotype and chronic periodontitis of Uighur patients.
- Author:
Liang-jun ZHONG
1
;
Yun-hui ZHANG
;
Jin-cai ZHANG
;
Jin-hong FENG
;
Ai-ling YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Chronic Disease; Female; Genetic Predisposition to Disease; Genotype; Humans; Interleukin 1 Receptor Antagonist Protein; Male; Middle Aged; Minisatellite Repeats; Periodontitis; genetics; Sialoglycoproteins; genetics
- From: Chinese Journal of Stomatology 2003;38(5):370-373
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate interleukin-1 receptor antagonist (IL-1ra) genotype and its association with the susceptibility of chronic periodontitis in Uighur patients of Xinjiang.
METHODSGenomic DNA was obtained from buccal swabs of 41 subjects with severe chronic periodontitis (CP), 43 subjects with moderate CP, 49 subjects with mild CP and 92 ethnically matched healthy control individuals. Genotypes of IL-1RN intron 2 VNTR was analyzed by SSP-PCR method. Then compared the differences in distribution of each genotype.
RESULTSA significant over-representation of IL-1RN intron 2 VNTR allele 2 was found in severe chronic periodontitis group.
CONCLUSIONIL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of severe chronic periodontitis in Uighur patients of Xinjiang.
