Stereoselective pharmacokinetics of tetrahydropalmatine in rats.
- Author:
Zhan-Ying HONG
1
;
Guo-Rong FAN
;
Yi-Feng CHAI
;
Jun WEN
;
Xue-Ping YIN
;
Yu-Tian WU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Area Under Curve; Berberine Alkaloids; chemistry; isolation & purification; pharmacokinetics; Chromatography, High Pressure Liquid; methods; Corydalis; chemistry; Female; Male; Molecular Structure; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Stereoisomerism
- From: Acta Pharmaceutica Sinica 2005;40(8):746-749
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the stereoselective pharmacokinetic process of tetrahydropalmatine (THP) in rats.
METHODSThe concentrations of tetrahydropalmatine enantiomers in rat plasma were determined by coupled achiral and chiral HPLC method. The differences in plasma concentrations and pharmacokinetic parameters between the two enantiomers were compared by paired t-test.
RESULTSThe plasma levels of l-THP were always higher than those of d-THP in eight rats. There was significant difference between the main pharmacokinetic parameters of the two enantiomers.
CONCLUSIONTetrahydropalmatine showed significant stereoselective pharmacokinetics in rats after an ig dose of the racemate.
