Design and synthesis of quinoxaline derivatives and their antitumor activities.
- Author:
Cui-Hua ZHAO
1
;
Yi CHEN
;
Jian DING
;
Wen-Hu DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antineoplastic Agents; chemical synthesis; chemistry; pharmacology; Cell Line, Tumor; drug effects; Humans; Molecular Structure; Quinoxalines; chemical synthesis; chemistry; pharmacology
- From: Acta Pharmaceutica Sinica 2005;40(9):814-819
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo design and synthesize novel quinoxaline derivatives as antitumor agents.
METHODSUsing 4-chloro-2-nitroaniline as a starting compound, followed by substitution, reductive cyclization, oxidation, and chlorination, to give the key intermediate 2,7-dichloroquinoxaline (7), which reacted with different phenolic compounds to afford quinoxaline derivatives.
RESULTSThe structures of the target molecules were characterized by elemental analysis, 1H NMR, MS, and IR.
CONCLUSIONAt concentration of 1 x 10(-4) mol x L(-1), some of the derivatives showed equal antitumor activities to XK469.
