Isolation and identification of two new epimer from the mother liquid of megestrol acetate.

Author: Zhong-Duo YANG ¹ ; Hua CHEN ; You-Fu WANG ; Li-Bo LIN ; Yuan-Chao LI
Author Information

1. Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
Publication Type:Journal Article
MeSH: Drug Contamination; Megestrol Acetate; chemical synthesis; chemistry; Molecular Conformation; Molecular Structure; Pregnanediones; chemistry; isolation & purification; Stereoisomerism
From: Acta Pharmaceutica Sinica 2005;40(9):830-833
CountryChina
Language:Chinese
Abstract:
AIMTo study the impurity in the drug megestrol acetate.
METHODSChromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis.
RESULTSTwo new epimers were isolated from the mother liquid of the drug megestrol acetate.
CONCLUSIONThese new epimers were identified as 17alpha-acetoxy-2beta,6alpha-dimethylprega-4-ene-3,20-dione (1) and 17alpha-acetoxy-2alpha,6alpha-dimethylprega-4-ene-3,20-dione (2).