Synthesis and antitumour activity of metal complexes of bacteriochlorophyll.
- Author:
Meng-Liang WANG
1
;
Ru-Bo CHANG
;
Dian-Sheng LIU
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; chemical synthesis; chemistry; pharmacology; Bacteriochlorophylls; chemistry; Cell Proliferation; drug effects; Cobalt; chemistry; Copper; chemistry; HL-60 Cells; cytology; Humans; K562 Cells; cytology; Metals, Heavy; chemistry; Nickel; chemistry; Organometallic Compounds; chemical synthesis; chemistry; pharmacology; Photosensitizing Agents; chemical synthesis; chemistry; pharmacology; Zinc; chemistry
- From: Acta Pharmaceutica Sinica 2005;40(10):920-923
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo find a new PDT sensitizer.
METHODSThere were four complexes (Cu, Zn, Co, Ni) synthesized through reaction of metal and deprivating-Mg bacteriochlorophyll in the organic solvent. Their antitumor action was detected by MTT.
RESULTSThe ultraviolet-visual spectrum and the fluorescence spectrum of these complexes showed that synthesis of these four complexes was succeeded. And these metal complexes have potent antitumor action on two kinds of leukaemic cells.
CONCLUSIONMetal bacteriochlorophylls as PDT sensitizers have very good properties and this is a way to develop new PDT sensitizers.
