Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives.
- Author:
Li-mei GAO
1
;
Peng YANG
;
Dan-qing SONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Benzylidene Compounds; chemical synthesis; chemistry; pharmacology; Blood Glucose; metabolism; Carbamates; chemical synthesis; chemistry; Cyclohexanes; chemical synthesis; chemistry; Hypoglycemic Agents; chemical synthesis; chemistry; pharmacology; Indoles; chemical synthesis; chemistry; Isoindoles; Mice; Molecular Structure; Phenylalanine; analogs & derivatives; chemical synthesis; chemistry; Piperidines; chemical synthesis; chemistry; Structure-Activity Relationship; Succinates; chemical synthesis; chemistry; pharmacology
- From: Acta Pharmaceutica Sinica 2005;40(12):1122-1126
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo design and synthesize new compounds of prandial glucose regulator with more simple structure.
METHODSThe target compounds were synthesized from diethyl succinate and benzaldehyde or 4-fluorobenzaldehyde by four-step reactions. Thus 18 compounds were synthesized. Their structures were comfirmed by NMR, MS and IR.
RESULTSSeventeen compounds had different hypoglycemic activity in mice, among them, 9 compounds had higher hypoglycemic activity and 6 compounds had character of prandial glucose regulator.
CONCLUSIONPart of the compounds have higher hypoglycemic activity deserve to be further investigated.
