Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln (Phen)2 (5-Fu)3 (NO3) (NO3 )2.
- Author:
Wen-yuan ZHONG
1
;
Zhi-xing HU
;
Shun-fang CHEN
;
Shu-yu JI
;
Yi-ping ZHOU
;
Ma-lin LI
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; chemical synthesis; chemistry; pharmacology; Cell Line, Tumor; Cell Proliferation; drug effects; Cerium; chemistry; Drug Synergism; Dysprosium; chemistry; Erbium; chemistry; Fluorouracil; chemistry; Gadolinium; chemistry; Humans; Lanthanoid Series Elements; chemistry; Lanthanum; chemistry; Phenanthrolines; chemistry; Samarium; chemistry; Structure-Activity Relationship; Yttrium; chemistry
- From: Acta Pharmaceutica Sinica 2005;40(11):997-1000
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the biochemistry of lanthanides, the cooperative action of inorganic and organic anti-tumor drugs.
METHODSA series of rare earth complexes were synthesized with Ln(NO3) 6H2O, Phen and 5-Fu. Their anti-tumor activity was measured by the improved MTT, SRB methods.
RESULTSThe formula of complex Ln[(Phen)2(5-Fu)3(NO3)](NO3)2(Ln = Y, La, Ce, Sm, Gd, Dy, Er; Phen = 1, 10-phenanthroline; 5-Fu = fluorouracil) was characterized by elemental analyses, molar conductivity, IR, TGA, and 13C NMR spectra. The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro.
CONCLUSIONThe complex might have anti-tumor cooperation action.
