Microalbuminuria is Independently Associated with Arterial Stiffness and Vascular Inflammation but not with Carotid Intima-Media Thickness in Patients with Newly Diagnosed Type 2 Diabetes or Essential Hypertension.
10.3346/jkms.2013.28.2.252
- Author:
Dong Il SHIN
1
;
Ki Bae SEUNG
;
Hye Eun YOON
;
Byung Hee HWANG
;
Suk Min SEO
;
Seok Joon SHIN
;
Pum Joon KIM
;
Kiyuk CHANG
;
Sang Hong BAEK
Author Information
1. Division of Cardiology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Albuminuria;
Vascular Stiffness;
Carotid Intima-Media Thickness;
Inflammation
- MeSH:
Albuminuria;
Area Under Curve;
C-Reactive Protein/analysis;
Cardiovascular Diseases/etiology;
Carotid Intima-Media Thickness;
Creatinine/urine;
Diabetes Mellitus, Type 2/complications/*diagnosis/physiopathology;
Female;
Humans;
Hypertension/complications/*diagnosis/physiopathology;
Logistic Models;
Male;
Middle Aged;
Multivariate Analysis;
Odds Ratio;
Risk Factors;
Vascular Stiffness
- From:Journal of Korean Medical Science
2013;28(2):252-260
- CountryRepublic of Korea
- Language:English
-
Abstract:
The association between microalbuminuria (MAU) and the indices of macrovascular complication in patients with newly diagnosed type 2 diabetes (D) or essential hypertension (H) was evaluated. Total 446 patients were classified into four groups according to the urinary albumin-to-creatinine ratio: MAU-D (n = 104), normoalbuminuria (NAU)-D (n = 114), MAU-H (n = 116), and NAU-H (n = 112). The indices of macrovascular complication including arterial stiffness evaluated by pulse-wave-velocity (PWV), carotid intima-media thickness (IMT), and vascular inflammation marked by high-sensitivity C-reactive protein (hsCRP) were assessed. PWV, IMT, and hsCRP were higher in patients with MAU than in those with NAU in both diabetes and hypertension groups. In both MAU-D and MAU-H groups, PWV and hsCRP levels were positively correlated with MAU level (MAU-D: r = 0.47, 0.41, MAU-H: r = 0.36, 0.62, respectively, P < 0.05). Additionally, PWV and hsCRP were independent factors predicting MAU (diabetes group: OR 1.85, 1.54, hypertension group: OR 1.38, 1.51, respectively, P < 0.001), but not IMT. MAU is independently associated with arterial stiffness and vascular inflammation but not with IMT in patients with newly diagnosed type 2 diabetes or essential hypertension, which emphasizes the importance of proactive clinical investigations for atherosclerotic complications in patients with MAU, even in newly diagnosed diabetes or hypertension.
