Interaction of metal complexes of bacterial chlorophyll with DNA.
- Author:
Meng-liang WANG
1
;
Ru-bo CHANG
;
Dian-sheng LIU
Author Information
- Publication Type:Journal Article
- MeSH: Bacteriochlorophylls; chemical synthesis; chemistry; pharmacology; Copper; chemistry; DNA; metabolism; Electrophoresis; HL-60 Cells; Humans; K562 Cells; Nickel; chemistry; Organometallic Compounds; chemical synthesis; chemistry; pharmacology; Protein Binding; Spectrophotometry, Ultraviolet; Zinc; chemistry
- From: Acta Pharmaceutica Sinica 2005;40(11):1054-1056
- CountryChina
- Language:Chinese
-
Abstract:
AIMUnderstanding the modes and activities of metal bacterial chlorophylls as PHD sensitizers with DNA.
METHODSThe modes and activities of the interaction of DNA and metal complexes of bacterial chlorophyll, which have been prepared by extraction and synthesis reaction, have been discussed according to the ultraviolet-visual spectrum and nucleic acid electrophoresis.
RESULTSIt indicates that the system of DNA and metal complexes have enchanced the interaction by the ultraviolet-visual spectrum. At the same time, it also indicates that metal complexes of bacterial chlorophyll and DNA have different combining way and have strong cutting effect in illumination by the nucleic acid electrophoresis.
CONCLUSIONThis paper proved that metal bacterial chlorophylls as PHD sensitizers have great advantage.
