Predictive Value of Conjointly Examined IL-1ra, TNF-R I, TNF-R II, and RANTES in Patients with Primary Glomerulonephritis.
10.3346/jkms.2013.28.2.261
- Author:
Rafal ZWIECH
1
Author Information
1. Department of Kidney Transplantation, Medical University of Lodz, Lodz, Poland. rafal.zwiech@umed.lodz.pl
- Publication Type:Original Article
- Keywords:
Immunosuppressive Treatment Outcomes;
Interleukin-1 Receptor Antagonist;
Primary Glomerulonephritis;
RANTES;
Receptors, Tumor Necrosis Factor
- MeSH:
Adult;
Cyclophosphamide/therapeutic use;
Female;
Glomerulonephritis/drug therapy/*metabolism/pathology;
Humans;
Immunosuppressive Agents/therapeutic use;
Interleukin 1 Receptor Antagonist Protein/*analysis/blood/urine;
Lymphocyte Activation;
Male;
Middle Aged;
Multivariate Analysis;
Predictive Value of Tests;
Receptors, Tumor Necrosis Factor, Type I/*analysis/blood/urine;
Receptors, Tumor Necrosis Factor, Type II/*analysis/blood/urine;
Steroids/therapeutic use;
T-Lymphocytes/immunology/metabolism
- From:Journal of Korean Medical Science
2013;28(2):261-267
- CountryRepublic of Korea
- Language:English
-
Abstract:
Interleukin-1 receptor antagonist (IL-1ra), tumor necrosis factor soluble receptors (sTNF-R) type I and II, and regulated upon activation, normal T-cell expressed and secreted (RANTES) play an important role in the modulation of primary glomerulonephritis (GN) course. The aim of the study was to assess whether pre-treatment measurements of IL-1ra, sTNF-R, and RANTES assessed conjointly may be useful as predicting factors in patients with GN. In 84 patients (45 males and 39 female) serum concentration (pg/mL) and urinary excretion (pg/mgCr) of cytokines were measured. After 12 months of therapy with steroids and cyclophosphamide the patients were divided into two subgroups: Responders (R) and Non-Responders (NR) according to the treatment results. The urinary IL-1ra, TNF-RI and RII were significantly higher in R than NR (1,732 vs 646 with P < 0.001, 13.1 vs 6.3 with P = 0.005, and 33.6 vs 14.4 with P = 0.012). The urinary RANTES excretion was increased in NR (79.6 vs 28.5; P < 0.001). The multivariable analysis showed that if conjointly assessed, only urinary IL-1ra, TNF-R I and R II, RANTES with 85% probability pointed the feature remission (R). In conclusion, the urinary excretion of IL-1ra, TNF-R I and R II, and RANTES examined conjointly are effective in predicting favorable response to immunosuppressive treatment in patients with GN.
