Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation.
- Author:
Lan DENG
1
;
Heng HUANG
;
Ming-xia XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Buxus; chemistry; Drugs, Chinese Herbal; chemical synthesis; isolation & purification; pharmacology; Lipid Peroxidation; drug effects; Malondialdehyde; metabolism; Molecular Structure; PC12 Cells; Plants, Medicinal; chemistry; Rats
- From: Acta Pharmaceutica Sinica 2006;41(2):121-124
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo search for compounds through structural modification of cyclovirobuxine D, using 20 or 21-aminosteroids as lead compound for the treatment of cerebrovascular diseases with better lipid peroxidation inhibitory activity.
METHODSAccording to rational drug design principle, a series of cyclovirobuxine D analogues were prepared, and their bioactivities were tested.
RESULTSFour new compounds were obtained and confirmed by spectra.
CONCLUSIONLipid peroxidation inhibitory effects of cyclovirobuxine D analogues were tested by using TBA method. Some compounds showed better activity than that of cyclovirobuxine D.
