Comparison of Immune Response by Virus Infection and Vaccination to 2009 Pandemic Influenza A/H1N1 in Children.
10.3346/jkms.2013.28.2.274
- Author:
Eun Kyeong KANG
1
;
Jung Sub LIM
;
Jun Ah LEE
;
Dong Ho KIM
Author Information
1. Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea.
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords:
Pandemic Influenza A;
Child;
Immune Response;
Natural Infection;
Vaccination
- MeSH:
Adolescent;
Antibodies, Neutralizing/blood;
Antibody Formation;
Child;
Child, Preschool;
Cross-Sectional Studies;
Hemagglutination Inhibition Tests;
Humans;
Infant;
Influenza A Virus, H1N1 Subtype/*immunology/metabolism;
Influenza, Human/epidemiology/*immunology/prevention & control;
Pandemics;
Vaccination
- From:Journal of Korean Medical Science
2013;28(2):274-279
- CountryRepublic of Korea
- Language:English
-
Abstract:
We aimed to compare the immune response induced by natural infection with 2009 pandemic influenza A/H1N1 (pH1N1) virus and by monovalent pH1N1 vaccination in children and adolescents. This cross-sectional clinical study was conducted at 3 hospitals in Korea from February to May 2010. A total of 266 healthy subjects aged from 6 months to 18 yr were tested for the presence of the antibody against pH1N1 using hemagglutination inhibition (HI) test. Information about pH1N1 vaccination and laboratory-confirmed pH1N1 infection history was obtained. The overall rate of HI titers of > or = 1:40 against pH1N1 was 38.7%, and the geometric mean titer (GMT) was 20.5. Immunogenicity of pH1N1 vaccination only was reflected by a 41.1% of seroprotection rate and a GMT of 22.5. Immunogenicity of natural infection only was reflected by a 61.0% of seroprotection rate and a GMT of 40.0. GMT was significantly higher in the subjects of natural infection group than in the subjects of pH1N1 vaccination group (P < 0.001). The immune responses induced by natural pH1N1 infection exceed those induced by pH1N1 vaccinations.
