Neural stem cells transplantation improved learning and memory abilities in Alzheimer's disease rat.
- Author:
Chun YANG
1
;
Qian ZHANG
;
Shu-chun WANG
;
Peng QIAO
;
Zhao ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; surgery; Animals; Disease Models, Animal; Hippocampus; surgery; Male; Maze Learning; Memory; Neural Stem Cells; transplantation; Neurons; transplantation; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation
- From: Chinese Journal of Applied Physiology 2007;23(2):159-161
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate whether transplantation of neural stem cells can ameliorate learning and memory abilities in Alzheimer's disease (AD) rats.
METHODSNeural stem cells were isolated from dentate gyrus of hippocampus of newborn rats. After labeled with Hoechst33258, neural stem cells were grafted into the hippocampus of AD rats. 2 or 4 weeks post transplantation, the rats underwent behavioral testing using Y-maze trial. Fluorescence observation and immunohistochemistry were used after the rats were sacrificed.
RESULTSNeural stem cells grafted into hippocampus of AD rats could not only survive well, but also possessed the capacity of continuous proliferation and migrate along the hippocampus.
CONCLUSIONNeural stem cells grafted into hippocampus of AD rats can not only survive well, possess the capacity of continuous proliferation, but also ameliorate memory defects in Alzheimer's disease rats.
