The relationship between the effects of curcumin on cerebral ischemia/reperfusion injury and immediately genic expressions of fos, Jun and NF-kappaB in hippocampal CA1 area and its significance in gerbils.
- Author:
Hong CAO
1
;
Jun LI
;
Guang-ming LI
;
Yao-qi WANG
;
Yin-ming ZENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; Brain Ischemia; metabolism; pathology; Curcumin; pharmacology; Gerbillinae; Hippocampus; drug effects; metabolism; Male; NF-kappa B; metabolism; Proto-Oncogene Proteins c-fos; metabolism; Proto-Oncogene Proteins c-jun; metabolism; Reperfusion Injury; metabolism; pathology
- From: Chinese Journal of Applied Physiology 2007;23(2):184-188
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the relationship between the effects of curcumin on cerebral ischemic/reperfusion injury and immediately genic expressions of Fos, Jun and NF-kappaB in hippocampal CA1 area.
METHODSGerbils were randomly divided into sham group (SH), ischemia/reperfusion group (I/R), curcumin group (CU) and solvent control group (SC). Forebrain ischemia was induced by occlusion of bilateral common carotid arteries. Observations were carried out in each group 15 min, 1 h, 2 h, 6 h, 1 d, 3 d, 5 d and 7 d after ischemia: open field test was used to examine the behavioral change, the apoptosis neurons in hippocampal CA1 region was counted, the expression of Fos, Jun and NF-kappaB in hippocampal CA1 was detected by SABC immunocytochemical technique.
RESULTSThe behavioral mark and the number of apoptosis neurons in hippocampal (CA1 region was much less in CU group than in I/R group (P < 0.01) The expression of Fos was more and the expression of Jun and NF-kappaB was less in CA1 area in CU group than in I/R group (P < 0.01).
CONCLUSIONCurcumin can significantly protect neurons against cerebral ischemia, increasing the expression Fos and decreasing the expression of Jun and NF-kappaB may be the protective mechanisms.
