Protective effect of sodium pyruvate on ischemia/reperfusion injury of rats subjected to hemorrhagic shock.
- Author:
Li-Dong GUAN
1
;
Zi-Ling WANG
;
Lian ZHAO
;
Bo WANG
;
Guang-Yi WANG
;
Guang-Zhi WEI
;
Hong ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aspartate Aminotransferases; blood; Disease Models, Animal; Kidney; metabolism; pathology; L-Lactate Dehydrogenase; blood; Liver; metabolism; pathology; Lung; metabolism; pathology; Male; Malondialdehyde; analysis; Peroxidase; analysis; Protective Agents; pharmacology; Pyruvic Acid; pharmacology; Rats; Rats, Wistar; Reperfusion Injury; blood; pathology; prevention & control; Shock, Hemorrhagic; blood; pathology
- From: Chinese Journal of Applied Physiology 2007;23(3):264-268
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the protective effect of sodium pyruvate on ischemia/reperfusion injury following hemorrhagic shock.
METHODSRat models of hemorrhagic shock were built up. When the shed blood was infused, the rats were also randomly provided by one of normal saline, glutathione and sodium pyruvate. Rats were killed 3 hours after the reperfusion, the activity of plasma lactate dehydrogenase (LDH) and glutamic-oxaloacetic transaminase (GOT), the level of tissue malondialdehyde (MDA) and the activity of tissue myeloperoxidase (MPO) were detected. Biopsy specimens were obtained to investigate morphological changes of the myocardial, hepatic, lung and renal tissue.
RESULTSThe activity of plasma LDH and GOT, the level of MDA of hepatic, lung and renal tissue and the activity of MPO of myocardial, lung and renal tissue decreased remarkably in group given sodium pyruvate compared with group given normal saline, and the effect of group given sodium pyruvate was more remarkable than group given glutathione.
CONCLUSIONThese data support the view that sodium pyruvate shows protective effect on ischemia/reperfusion injury following hemorrhagic shock. It is possibly relevant to scavenging of oxygen free radicals, reduction of neutrophil, and anti-inflammatory response.
