Experimental studies on antiarrhythmic effect of jumi extraction.
- Author:
Ce XU
1
;
Ting-mei YE
;
Li ZHU
;
Ying-ying CHEN
;
Yue-liang SHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Arrhythmia Agents; therapeutic use; Arrhythmias, Cardiac; chemically induced; drug therapy; Female; Male; Mice; Plant Extracts; therapeutic use; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2007;23(4):399-402
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the antiarrhythmic effect of jumi (JM) extraction.
METHODSThe conventional antiarrhythmic methods were used.
RESULTSAdministration of JM extraction reduced the occurrence of ventricular fibrillation induced by chloroform in a dose-dependent manner in mice. Quinidine significantly decreased the number of ventricular premature beats and ventricular tachycardia, shortened the duration of arrhythmia in aconitine-treated rats. But JM extraction had no effect on aconitine-induced arrhythmia. Compared with control, arrhythmia score was lower in ischemia/reperfusion rats which pretreated with 2.0 g/kg of JM extraction.
CONCLUSIONJM extraction has obvious protection effects in chloroform- and ischemia-induced arrhythmia, but has no effect in aconitine-induced arrhythmia.
