The protective effect of nicotine on dopaminergic neuron of Parkinson's disease mice.
- Author:
Yue LI
1
;
De-qin YU
;
Yan PENG
;
Yan-hui FENG
;
Dong-mei ZHANG
;
Jie ZHAO
;
Wan-qin ZHANG
;
Yi-ping SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Caudate Nucleus; ultrastructure; Disease Models, Animal; Dopaminergic Neurons; drug effects; Female; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; pharmacology; Nicotine; pharmacology; Parkinson Disease; drug therapy; Tyrosine 3-Monooxygenase; metabolism; gamma-Aminobutyric Acid; metabolism
- From: Chinese Journal of Applied Physiology 2007;23(4):425-429
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the protective effect of nicotine on dopaminergic neurons and its mechanisms in mice with Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
METHODSC57BL/6J mice were injected with MPTP for 8 days to establish PD model. Nicotine was given for 10 days in the pretreatment group. Animals were examined behaviorally with the pole test and traction test. Tyrosine hydroxylase (TH) and gamma-aminobutyric acid (GABA) were investigated by the immunocytochemistry (ICC) method. The ultrastructural changes of caudate nucleus(CN) were observed by electron microscope.
RESULTSThe results showed that pretreatment nicotine could improve the dyskinesia of PD mice markedly. Simultaneously, TH (P < 0.01) neurons and GABA (P < 0.05) neurons were much more in the pretreatment group when compared with those in the model group. The ultrastructural injury of the pretreatment group was also ameliorated.
CONCLUSIONNicotine has a protective effect on the dopaminergic neurons in the MPTP-treated mice.
