Main regulatory factors for differentiation, development and function of naturally occurred CD4+ CD25+ regulatory T cells.
- Author:
Ming WU
1
;
Yan-Hui XUE
Author Information
1. Department of Hematology, Huashan Hospitals, Fudan University Shanghai Medical College, Shanghai 200040, China.
- Publication Type:Journal Article
- MeSH:
Animals;
CD4 Antigens;
metabolism;
Cell Differentiation;
immunology;
Cells, Cultured;
Dendritic Cells;
immunology;
Forkhead Transcription Factors;
physiology;
Humans;
Interleukin-2;
physiology;
Interleukin-2 Receptor alpha Subunit;
metabolism;
T-Lymphocytes, Regulatory;
cytology;
immunology;
metabolism;
Thymus Gland;
cytology;
Transforming Growth Factor beta;
physiology
- From:
Journal of Experimental Hematology
2008;16(1):207-212
- CountryChina
- Language:Chinese
-
Abstract:
Naturally occurred CD4(+)CD25(+) regulatory T cells derived from thymus. It plays an important role in self-tolerance and allograft-tolerance through cell-contact dependent mechanism. This review described the advances of study on the probable regulatory factors of the naturally occurring regulatory T cells, such as Foxp3, IL-2, TGF-beta(1), dendritic cells and CTLA-4. As a marker of Treg, the expression of Foxp3 could be used to identify regulatory T cells. The combination of interferon 2 and IL-2Ralpha would activate Treg and promote its proliferation through the phosphorylation of STAT5. TGF-beta(1) on the cell surface may influence the function of Treg, while the secretion type of TGF-beta may promote the proliferation of Treg. Dendritic cells can positively or negatively regulate Treg, which depends on the signal transduction pathway. CTLA-4 expressed on the surface of Treg might bind to the B7 molecule on the DC, effective cell or Treg itself directly or indirectly regulate Treg.
