An update on beta2 integrin LFA-1 and ligand ICAM-1 signaling.
- Author:
Meng LI
1
;
Chun-Ji GAO
Author Information
1. Department of Hematology, PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Intercellular Adhesion Molecule-1;
metabolism;
physiology;
Ligands;
Lymphocyte Function-Associated Antigen-1;
metabolism;
physiology;
Lymphocytes;
cytology;
immunology;
metabolism;
Phosphorylation;
Signal Transduction;
physiology;
Talin;
metabolism
- From:
Journal of Experimental Hematology
2008;16(1):213-216
- CountryChina
- Language:Chinese
-
Abstract:
LFA-1 and ICAM-1 mediate a bi-directional signaling across the cell membrane which is essential for biological functions of lymphocyte, including exudation, activation, adhesion, immunosurveillance as well as immuno-logical synapse formation. The signal transducing is a dynamic process and dependent on the binding capacity between LFA-1 and ICAM-1. The affinity and the avidity of LFA-1 are two major regulation forms in this process. Phosphorylation of LFA-1 and cytoskeleton protein talin 1 play a critical role in signal transducing. In biology of lymphocyte, LFA-1 and ICAM-1 interaction forms the co-stimulatory signal to promote activation, proliferation and division. In this article the regulation of binding capacity between LFA-1 and ICAM-1, the regulation of LFA-1 subunit phosphorylation, the role of talin1 in signaling transduction of LFA-1 and ICAM-1, the synergic stimulatory signaling of LPA-1 and ICAM-1 were reviewed.
