Single nucleotide polymorphism of interferon-gamma gene +874 T/A in patients with aplastic anemia.
- Author:
Hong CHANG
1
;
Jia-You ZHANG
;
Wen-Tong MENG
Author Information
1. Department of Hematology, Laboratory of Blood Genetics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China. changhonghx@163.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Alleles;
Anemia, Aplastic;
genetics;
Base Sequence;
Female;
Genetic Predisposition to Disease;
genetics;
Genotype;
Humans;
Interferon-gamma;
genetics;
Male;
Middle Aged;
Molecular Sequence Data;
Polymorphism, Single Nucleotide;
Young Adult
- From:
Journal of Experimental Hematology
2008;16(2):325-327
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate whether the single nucleotide polymorphism (SNP) of interferon-gamma (IFN-gamma) +874 T/A correlates with aplastic anemia. Amplification refractory mutation system-polymerase chain reaction was used to amplify the polymorphism gene segment of IFN-gamma +874 A/T from 54 aplastic anemia patients and 51 healthy adults. The results showed that the frequency of IFN-gamma +874 TT genotype and T allele was significantly higher in patients with aplastic anemia than that in the healthy adults (42.6% vs 17.6%, chi2=13.780, p=0.01; 65.7% vs 39.2%; chi2=14.811, p<0.001). In conclusion, IFN-gamma +874 A/T gene polymorphism is correlated with the susceptibility of aplastic anemia, but not significantly correlated with the the severity of aplastic anemia.
