Advance of research on SDF-1/CXCR4 axis and angiogenesis in leukemia--review.
- Author:
Cui-Hua BAO
1
;
Qi-Tu HE
Author Information
1. Department of Hematology, The First Affiliated Hospital, Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China.
- Publication Type:Journal Article
- MeSH:
Chemokine CXCL12;
metabolism;
physiology;
Humans;
Leukemia;
metabolism;
Neovascularization, Pathologic;
Receptors, CXCR4;
metabolism;
physiology
- From:
Journal of Experimental Hematology
2008;16(2):447-451
- CountryChina
- Language:Chinese
-
Abstract:
The study on biological effects of SDF-1/CXCR4 axis composed of stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 is progressing rapidly in the recent years. The SDF-1/CXCR4 axis plays an important role in occurrence and development of tumors and closely correlate with angiogenesis of tumors. This review focuses the progress of study on SDF-1/CXCR4 axis and angiogenesis in leukemia including SDF-1/ and its receptor CXCR4, the expression of SDF-1/CXCR4 axis in leukemic cells, the mechanism of relation between SDF-1/CXCR4 axis and angiogenesis in leukemia, the application of inhibitors against SDF-1/CXCR4 in treatment of angiogenesis and so on.
