Significance of id4 promoter methylation in monitoring AML patients with completely remission.
- Author:
Yu ZHAO
1
;
Quan-Shun WANG
;
Hong-Hua LI
;
Jian BO
;
Li-Ping DOU
;
Yu JING
;
Shu-Hong WANG
;
Li YU
Author Information
1. Department of Hematology, General Hospital of PLA, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
DNA Methylation;
Humans;
Inhibitor of Differentiation Proteins;
genetics;
Leukemia, Myeloid, Acute;
genetics;
metabolism;
Neoplasm, Residual;
diagnosis;
genetics;
Promoter Regions, Genetic;
genetics
- From:
Journal of Experimental Hematology
2008;16(3):476-478
- CountryChina
- Language:Chinese
-
Abstract:
The study was purposed to investigate the significance of id4 gene promoter methylation in monitoring AML patients with complete remission (CR). Methylation specific-PCR (MS-PCR) were used to detect the status of promoter methylation of id4 gene in bone marrow samples from AML patients with CR who had accepted induction with DA or IA and 4 to 5 consolidation chemotherapy with Ara-C. The results showed that in the all 32 patients, 15 were found to show id4 promoter methylation and 7 out of the 15 were found relapsed or tendency to relapse in the following-up period. While all the 17 patients with id4 unmethylation were still in their CR status in the same period. In conclusion, id4 promoter methylation might be a predictor for relapse of AML patients with CR in certain degree.
