Analysis of the dynamic change of TF, TFPI and IL-1beta in plasma of patients with acute leukemia.
- Author:
Yan SUN
1
;
Ri-He WU
;
Wei-Hong LIU
;
Jin-Wei HUANG
Author Information
1. Lishui Municipal Central Hospital, Lishui 323000, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Acute Disease;
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Biomarkers, Tumor;
blood;
Child;
Female;
Humans;
Interleukin-1beta;
blood;
Leukemia;
blood;
Lipoproteins;
blood;
Male;
Middle Aged;
Thromboplastin;
metabolism;
Young Adult
- From:
Journal of Experimental Hematology
2008;16(3):493-496
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to explore the significance of tissue factor (TF), tissue factor pathway inhibitor (IFPI) and interleukin-1beta (IL-1beta) in the evaluation of development, curative effect and prognosis of AL patients. ELISA was used to detect the levels of TF, TFPI and IL-1beta in plasma of 20 healthy individuals and 24 newly diagnosed AL patients. All the three indications of patients were measured in different stages including pre-chemotherapy phase, at 72 hours after chemotherapy, complete remission phase. The results showed that as compared with normal control, levels of TF, TFPI and IL-1beta in plasma of AL patients during pre-chemotherapy phase were higher (p < 0.01); as compared with pre-chemotherapy phase, levels of TF, IL-1beta were elevated at 72 hours after -chemotherapy (p < 0.05). However, the levels of TFPI was much lower than that of 72 hours after chemotherapy (p < 0.01). 16 out of 24 patients got complete remission, there was no difference of TF, TFPI and IL-1beta between complete remission group and normal control group. It is concluded that the levels of TF, TFPI and IL-1beta in plasma can be used as the indicators for understanding clinical features, evaluating disease status and predicting prognosis in acute leukemia patients.
