Clinical and prognostic analysis of 125 cases of non-Hodgkin's lymphoma.
- Author:
Lin LIU
1
;
Min ZHANG
;
Ping ZOU
Author Information
1. Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Bone Marrow;
pathology;
Child;
Child, Preschool;
China;
Female;
Humans;
Infant;
L-Lactate Dehydrogenase;
metabolism;
Lymphoma, B-Cell;
diagnosis;
Lymphoma, Non-Hodgkin;
diagnosis;
mortality;
pathology;
Lymphoma, T-Cell;
diagnosis;
enzymology;
Male;
Middle Aged;
Prognosis;
Retrospective Studies;
Survival Rate;
Young Adult
- From:
Journal of Experimental Hematology
2008;16(3):547-550
- CountryChina
- Language:English
-
Abstract:
This study was to investigate the predictive factors influencing prognosis of non-Hodgkin's lymphoma (NHL). The clinical data on 125 cases of NHL were analyzed retrospectively. The results indicated that in 125 cases, the incidence of B cell NHL (B-NHL) was 68%, T cell NHL (T-NHL) was 28%, and uncertained cases were 4%. B-NHL was with more bone marrow involvement, while T-NHL was associated with more presence of B symptom, increased lactate dehydrogenase (LDH), advanced clinical stage and higher International Prognostic Index (IPI) scores. For T-NHL and B-NHL, the 3-year overall survival (OS) rate was 41.07% and 71.64% respectively. Age, B symptom, LDH level, and clinical stage were associated with OS. Immunophenotyping was not identified as a significant prognostic factor. The incidence of born marrow involvement was 31.2%, mainly in B-NHL. The involvement manner had no relationships with age, B symptom, LDH level and T/B immunophenotyping. Diffuse bone marrow involvement was often linked with hepatosplenomegaly, and its OS was shorter than that focal manner. In conclusion, age, B symptom, LDH level and clinical stage affect NHL survival, while immunophenotyping was not an independent prognostic factor for NHL. The manner of bone marrow involvement helped to predict prognosis.
