Effect of curcumin on pulmonary hypertension and wall collagen of pulmonary arterioles of chronic hypoxic hypercapnic rats.
- Author:
Quan LIN
1
;
Liang-xing WANG
;
Shao-xian CHEN
;
Xiang-feng ZHOU
;
Xiao-ying HUANG
;
Xiao-fang FAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arterioles; drug effects; metabolism; Collagen Type I; metabolism; Curcumin; pharmacology; Extracellular Matrix; metabolism; Hypercapnia; metabolism; physiopathology; Hypertension, Pulmonary; metabolism; physiopathology; Hypoxia; metabolism; physiopathology; Male; Pulmonary Artery; drug effects; metabolism; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Applied Physiology 2006;22(3):257-261
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effect of curcumin on pulmonary arterial pressure and type I collagen of pulmonary arterioles in pulmonary hypertensive rats induced by chronic hypoxia and hypercapnia.
METHODSThirty six rats were randomly divided into three groups: normal control group (NC), hypoxic hypercapnic group (HH) and hypoxic hypercapnia + curcumin group (HC). Collagen I in pulmonary arterioles was observed by the technique of immunohistochemistry.
RESULTS(1) The findings from hemodynamics showed that the mPAP in group HH was significantly higher than that in group NC and HC. Differences of mCAP among groups were not significant (P > 0.05). (2) Light microscopy showed the value of WA/TA (vessel wall area/total area), SMC (the density of medial smooth muscle cells) and thickness of pulmonary arterial media smooth cell layer(PAMT) were significantly higher in group HH than group NC (P < 0.01) and group HC (P < 0.01). (3) Electron microscopy showed that structure of the endothelial cells in pulmonary arterioles in group HC was near to normal, and the proliferation of medial smooth muscle cells and collagen fibers in adventitia was much lighter than those of group HH. (4) Expression of collagen I in pulmonary arterioles was significantly higher in group HH than group NC (P < 0.01) and group HC (P < 0.01).
CONCLUSIONCurcumin can decrease pulmonary arterial pressure, improve pulmonary vessel remodeling and inhibit the deposition of collagen I in pulmonary arterioles.
