Effects of soybean isoflavones on the cell cycles, the cell apoptosis and the proliferation of spleen in radiated mice.
- Author:
Li LIU
1
;
Hong JIN
;
Xian-Yuan WANG
;
Zhi-Qin XU
;
Wen-Kao NAN
;
Pei-Bing LI
;
Jian-Quan WU
;
Lan-Xing GAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; radiation effects; Cell Cycle; drug effects; radiation effects; Cellular Structures; Isoflavones; pharmacology; Male; Mice; Mice, Inbred Strains; Radiation, Ionizing; Soybeans; Spleen; cytology
- From: Chinese Journal of Applied Physiology 2006;22(4):497-500
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study effect of soybean isoflavones (SI) on spleen in radiated mice.
METHODS90 male mice were randomly divided into control group, radiated group, radiated plus 0.5% dose SI group. After 2-week feeding, the mice received 4.0 Gy 137Cs gamma-radiation, the cell cycles, cell apoptosis and proliferation on the spleen and the spleen index were observed in radiated after 12 h, 24 h, 1 week and 2 weeks.
RESULTSAfter the mice were radiated, the spleen were significantly atrophy, the rate of the cell apoptosis and the cell cycles of G0-G1 phase in splenocytes were significantly increased (P < 0.01), the cell cycles rate of S phase and the proliferation index were significantly decreased in spleen (P < 0.05). Compared with radiated group, the spleen atrophy and the rate of the cell cycles of G0-G1 phase were significantly decreased (P < 0.05), and the cell cycles of G2-M phase and the proliferation index were significantly increased (P < 0.05) in the mice supplied 0.5% soybean isoflavones.
CONCLUSIONThe soybean isoflavones could significantly increase spleen radioprotective effect in mice.
