Effects of extremely low magnetic field on acute and chronic arthritis of rats.
- Author:
Xiu-Qi BAO
1
;
Yi-Jun SHI
;
Yu-Xia ZHANG
;
Yang YU
;
Tao SONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arthritis, Experimental; metabolism; pathology; Disease Models, Animal; Edema; prevention & control; Freund's Adjuvant; adverse effects; Interleukin-6; metabolism; Magnetic Fields; Male; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; metabolism
- From: Chinese Journal of Applied Physiology 2006;22(4):505-508
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effects of extremely low magnetic field on acute and chronic arthritis of rats.
METHODSThe acute arthritis animal models were built by the right thenar hypodermic injection of carrageenan. Then they were exposed to magnetic field for 6 hours and 8 hours, respectively. The chronic arthritis animal models were built by the right thenar hypodermic injection of complete freund's adjuvant. They were exposed to magnetic field for 7 days and 6 hours each day after the secondary affection appeared 15 days later. The swelling and inflammatory cytokine were observed in both the acute and chronic arthritis models.
RESULTSThe ankle and thenar swellings decreased in both the acute and chronic arthritis models after different time exposure. The cytokine of serum and articular lixivium did not change in 6 hours exposed groups of acute arthritis models. The serum IL-6 and articular lixivium IL-6, TNF-alpha decreased compared with sham groups. Though the rest indexes were unchanged, they had the tendency of decrease.
CONCLUSIONThe extremely low magnetic field has the effects of restraining acute and chronic arthritis of rats, and can also partially restrain the cytokines when the rats were exposed for 8 hours. The mechanisms need to be further investigated.
