The changes and their clinical significance of D-dimer and platelet glycoprotein in patients with coronary heart disease.
- Author:
Jian-lin MA
1
;
Sheng WANG
;
Xin-ming LI
;
Zhe-tan SU
;
Bin LI
;
Guan-liang CHEN
;
Jin LI
;
Wei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Angina, Unstable; diagnosis; metabolism; Case-Control Studies; Coronary Disease; diagnosis; metabolism; Female; Fibrin Fibrinogen Degradation Products; metabolism; Humans; Male; Middle Aged; Myocardial Infarction; diagnosis; metabolism; Platelet Glycoprotein GPIIb-IIIa Complex; metabolism; Platelet Membrane Glycoprotein IIb; metabolism; Platelet Membrane Glycoproteins; metabolism
- From: Chinese Journal of Cardiology 2005;33(8):724-726
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the changes and their clinical significance of D-dimer and platelet glycoprotein (GP) in patients with coronary heart disease.
METHODSD-dimer and GP in 20 patients with stable angina (SA group), 48 patients with unstable angina (UA group), and 20 control cases were measured. The changes of D-dimer and GP in patients with and without coronary events were compared. The sensitivity of those changes in the diagnosis of coronary events was evaluated.
RESULTSThere were significant differences of D-dimer and GP between UA group and SA group or control group (P < 0.01), while there was no significant difference between SA group and control group (P > 0.05). There were also significant differences of D-dimer and GP between patients with coronary events and patients without coronary events (P < 0.05). In the sensitivity test for detecting coronary events, D-dimer and GPIIb, GPIIIa were much more sensitive than other parameters.
CONCLUSIONSD-dimer and GPIIb, GPIIIa may be regarded as the indexes of coronary thrombosis and used for predicting the severity of coronary events.
