Association of polymorphism in alpha-adducin gene with antihypertensive effect of Hydrochlorothiazide.
- Author:
Shou-ling WU
1
;
Dong-qing LI
;
Hong-fen LI
;
Qing YU
;
Yun LI
;
Hai-yan ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; therapeutic use; Blood Pressure; Calmodulin-Binding Proteins; genetics; Female; Humans; Hydrochlorothiazide; therapeutic use; Hypertension; drug therapy; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Single-Blind Method; Treatment Outcome
- From: Chinese Journal of Cardiology 2005;33(10):880-884
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association between G614T single nuclear polymorphism (SNP) of the alpha-adducin gene and the antihypertensive effect of hydrochlorothiazide (HCTZ) in essential hypertensive (EH) patients.
METHODSEight hundred twenty nine EH patients were given 12.5 mg HCTZ/d for six weeks. Alpha-adducin gene G614T SNP in the tenth exon was determined by PCR-RFLP in 754 patients with complete records. All the patients were grouped according to TT, GT and GG genotypes.
RESULTSAfter 6 weeks of HCTZ treatment, the decreases in DBP and MAP of patients carrying 614T allele of alpha-adducin were significantly greater than that of those carrying GG homozygotes (P < 0.05). The decreases in SBP and MAP were significantly greater in patients with the TT genotype as compared with GT or GG genotype (P < 0.05). The effective rate of BP fall by HCTZ was higher in patients with TT genotype than those with GT or GG genotype (P < 0.05). Multivariate stepwise regression analysis showed that the TT genotype and the baseline SBP were the two major predictors affecting the decrease in SBP.
CONCLUSIONThe present study suggests that the alpha-adducin G614T polymorphism is associated with the antihypertensive effect of HCTZ, which is more effective in patients with TT genotype.
