The relationship between the beta-2-adrenergic receptor gene +46 Arg 16/Gly variant and serum level of low density lipoprotein-cholesterol in Kazakans of Xinjiang.
- Author:
Nan-fang LI
1
;
Qin LUO
;
Ling ZHOU
;
Tao LI
;
De-lian ZHANG
;
Wei-jin OUYANG
;
Ke-ming ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Alleles; Asian Continental Ancestry Group; genetics; Cholesterol, LDL; blood; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Receptors, Adrenergic, beta-2; genetics
- From: Chinese Journal of Cardiology 2005;33(12):1071-1074
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the distribution of beta-2-AR +46 A-->G variant in Kazakans of Xinjiang and the relationship of the variant with low density lipoprotein-cholesterol (LDL-C) level in this population.
METHODSThe genotypes of beta-2-AR gene Arg16/Gly variant were detected by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 506 Kazakans with age from 30 to 69, and its distribution and relationship to LDL-C level were investigated.
RESULTS(1) The frequencies of genotypes AA, AG, GG and alleles A, G of beta-2-AR +46 variant in this population were 0.310, 0.455, 0.235 and 0.538, 0.462 respectively, which were accorded with Hardy-Weinberg equilibrium. (2) The Gly16/Gly genotype had highest LDL-C level in the three genotypes, and were significantly higher than Arg16/Gly genotype (P < 0.05). (3) Comparing the effect of beta-2-AR gene +46 variant on serum lipid in males with females, we found that females with Gly16/Gly genotype had the highest level of serum LDL-C.
CONCLUSIONSThese data show that Gly16/Gly genotype of beta-2-AR gene +46 A-->G variant is associated with higher level of serum LDL-C in this population, especially in female.
