Proliferation and Apoptosis in Prostatic Hypertrophy.
- Author:
Hak Ryong CHOI
1
;
Hea Soo KOO
Author Information
1. Department of Urology, College of Medicine, Ewha Womans University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Benign prostatic hyperplasia;
Proliferation;
Apoptosis
- MeSH:
Apoptosis*;
Epithelial Cells;
Prostate;
Prostatic Hyperplasia*
- From:Korean Journal of Urology
1998;39(5):454-458
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Volumetric change of prostate is the result of unbalanced proliferation and apoptosis. We investigated the characteristics of proliferation and apoptosis in hypertrophic prostate. MATERIALS AND METHODS: Proliferative and apoptotic rates were quantitated with immunoprofiles of proliferative cell nuclear antigen(PCNA) and apoptotic body with 46 paraffin-embeded BPH specimen. When the rate of proliferation was higher than that of apoptosis, we defined as proliferation active group. RESULTS: Proliferation and apoptotic rates of stromal and epithelial cells were 4.5%, 2.9% and 1.9%, 1.1%, respectively(p<0.05). There was modest correlation between stromal volume and the proliferation rate of stromal cells(p<0.05, R=0.3209). There was no volumetric difference in the prostate between proliferation active and inactive group(p> 0.05). CONCLUSIONS: These results demonstrate that stromal proliferation is the main cause of prostatic hypertrophy. The unbalance between proliferation and apoptosis of prostatic cells seems to be unsteady in time.
