Effect of berberine on pharmacokinetics of digoxin after oral administration to rats.
- Author:
Yang JU
1
;
Wen QIU
;
Xuehua JIANG
;
Changxiao LIU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Animals; Berberine; pharmacology; Digoxin; administration & dosage; pharmacokinetics; Dose-Response Relationship, Drug; Drug Interactions; Male; Rats; Rats, Wistar; Time Factors; Tissue Distribution; drug effects
- From: China Journal of Chinese Materia Medica 2011;36(7):918-921
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effects of berberine (BBR) on the pharmacokinetics of digoxin (DIG) in rats.
METHODRats were randomly assigned into DIG, low dose-BBR, middle dose-BBR and high dose-BBR group. After singe or a 2-week ig pretreatment with BBR, serum DIG concentration was determined by radioimmunoassay. Pharmacokinetic calculations were performed on each individual set of data using 3P97 practical pharmacokinetic software.
RESULTNo significant difference was found between the control and 10 mg x kg(-1) BBR combined group. After pretreatment with BBR (30, 100 mg x kg(-1)), the pharmacokinetic parameters of ig DIG were significantly altered. The AUC(0-t) of DIG with BBR increased by 33% and 70% (single), 27% and 75% (2-week), respectively.
CONCLUSIONBBR increases bioavailability of DIG, which may be related to its inhibition effect on intestinal P-gp.
