Protective effects of shaoganduogan on hepatocyte mitochondria in subacute liver injury rat induced by carbon tetrachloride.
- Author:
Jun SONG
1
;
Junning ZHAO
;
Xiaodong WANG
;
Ying DAI
;
Zhiwen DENG
;
Jinhai YI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Carbon Tetrachloride; adverse effects; Chemical and Drug Induced Liver Injury; pathology; Drugs, Chinese Herbal; pharmacology; Hepatocytes; drug effects; pathology; Male; Malondialdehyde; metabolism; Mitochondria; drug effects; enzymology; metabolism; ultrastructure; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2011;36(7):931-934
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effect of Shaoganduogan (SGDG) on serum transaminase, liver pathology and hepatocyte mitochondria in rat with subacute liver injury induced by carbon tetrachloride.
METHODSubacute liver injury of rats were induced by carbon tetrachloride, and cured by different doses of SGDG through intragastric administration. The activity of serum ALT, AST, liver pathology and ultrastructure, activity of ATPase, SOD and content of MDA of hepatocyte mitochondria were observed.
RESULTSGDG can remarkably reduce the transaminase, alleviate the degeneration and necrosis of liver cells ,enhance activity of Na+ -K+ ATPase, Ca2+ ATPase, SOD, reduce content of MDA of mitochondria, alleviate ultrastructure change of mitochondria, reduce section area, perimeter equivalent diameter and average optical density perimeter of liver cells.
CONCLUSIONSGDG has obvious effect of liver protection, the mechanisms are related with alleviating mitochondria injury.
