Effects of glycyrrhiza extract on pharmacokinetics property of daphnetin in rats.
- Author:
Letian CHEN
1
;
Liuqing DI
;
Hui LIU
;
Jinjun SHAN
;
Xiaoli ZHAO
;
Wei ZHOU
;
Baochang CAI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Drug Interactions; Drugs, Chinese Herbal; pharmacology; Glycyrrhiza; chemistry; Rats; Rats, Sprague-Dawley; Tissue Distribution; drug effects; Umbelliferones; pharmacokinetics
- From: China Journal of Chinese Materia Medica 2011;36(7):935-938
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo research the influence of glycyrrhiza extract on the pharmacokinetics characteristic parameters of daphnetin, which was aimed to explore the rationality of concert application of drugs.
METHODThe rats received intragastric administration of daphnetin and glycyrrhiza extract containing the same daphnetin respectively. The blood concentration of daphnetin was assayed by LC-MS. The data was processed by program DAS2.1.1.
RESULTGlycyrrhiza extract can reduce the t(1/2), tmax and Ke of daphnetin, while increased the Ka and AUC(0-infinity).
CONCLUSIONGlycyrrhiza extract promoted the oral absorption of daphnetin, slowed down the elimination and increased the biological availability.
