Pharmacokinetics of ginkgolides sustained-release tablet.
- Author:
Miaomiao JIN
1
;
Qingming GUO
;
Xiaoping SUN
;
Xuan ZHANG
;
Yaozhong LV
;
Wei XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; methods; Delayed-Action Preparations; administration & dosage; pharmacokinetics; Dogs; Ginkgolides; administration & dosage; analysis; pharmacokinetics; Lactones; analysis; Male; Mass Spectrometry; methods; Quality Control; Tablets; administration & dosage; pharmacokinetics; Therapeutic Equivalency
- From: China Journal of Chinese Materia Medica 2011;36(8):1011-1014
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pharmacokinetics and bioavailability of ginkgolides sustained-release tablet and conventional tablet in Beagle dogs.
METHODThe concentrations of ginkgolides in plasma were determined by LC-MS. The main pharmacokinetic parameters of ginkgolides sustained-release tablet and conventional tablet in vivo were obtained using Pharmacokinetic software DAS 2.0.
RESULTThe C(max) of grinkgolide A in ginkgolide sustained-release tablet and conventional tablet were 443.51, 1 039.30 microg x L(-1), respecitvely. t(max) were 2.92, 1.08 h, respectively. AUC(0-12h) were 1 808.21, 2 041.37 h x microg(-1) x L(-1), respectively. MRT were 5.18, 3.18 h, respectively. The relative bioavailability of ginkgolides A was 88.58%. The C(max) of ginkgolide B in ginkgolide sustained-release tablet and conventional tablet were 407.13, 547.38 microg x L(-1), respectively. t(max) were 2.92, 1.08 h, respectively. AUC(01-12 h) were 1 987.31, 1 748.04 h x microg(-1) x L(-1), respectively. MRT were 6.05, 4.98 h, respectively. The relative bioavailability of ginkgolides B was 113.69%.
CONCLUSIONThe ginkgolides sustained-release tablets have good sustained release characteristics and are bioequivalent to the reference formulation.
