Pharmacokinetics of Guizhi Fuling capsule in Beagle dogs.
- Author:
Kejin ZHU
1
;
Xiaoping SUN
;
Xiujuan CHANG
;
Jianping QIN
;
Xinyong LV
;
Zhenzhong WANG
;
Wei XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Amygdalin; blood; Animals; Area Under Curve; Benzoates; blood; Bridged-Ring Compounds; blood; Capsules; administration & dosage; pharmacokinetics; Chromatography, High Pressure Liquid; methods; Dogs; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; Glucosides; blood; Half-Life; Male; Monoterpenes; Tandem Mass Spectrometry; methods
- From: China Journal of Chinese Materia Medica 2011;36(8):1015-1018
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate pharmacokinetic parameters of peoniflorin, albiflorin and amygdaloside after administration of Guizhi Fuling capsule in beagle dogs.
METHODPlasma was collected from forelimb vein of Beagle dogs after oral administration of Guizhi Fuling capsule. HPLC-MS/MS method was used to determine the concentrations of constituents in plasma. The pharmacokinetic parameters were analyzed by program DAS 2.0.
RESULTThe limit of quantitation of peoniflorin, albiflorin and amygdaloside were 0.25, 2.64, 0.04 microg x L(-1), respectively. After administrated with different doses, half-life of peoniflorin in dogs were 4.33, 3.62 h, albiflorin were 6.16, 5.91 h, amygdaloside were 2.43, 1.32 h. The AUC(0-t) of all components were related to dose.
CONCLUSIONThe pharmacokinetic course of peoniflorin, albiflorin and amygdaloside can be described by two-compartment model, and these components have high expose.
