Study on chemical constituents from branches and leaves of Polyalthia nemoralis.
- Author:
Ziming LU
1
;
Qingjian ZHANG
;
Ruoyun CHEN
;
Dequan YU
Author Information
- Publication Type:Journal Article
- MeSH: Alkaloids; chemistry; isolation & purification; pharmacology; Antineoplastic Agents, Phytogenic; chemistry; pharmacology; Aporphines; chemistry; isolation & purification; pharmacology; Cell Line, Tumor; Cell Survival; drug effects; Chromatography, Agarose; methods; Coumaric Acids; chemistry; isolation & purification; pharmacology; Gallic Acid; analogs & derivatives; chemistry; isolation & purification; pharmacology; Humans; Kaempferols; chemistry; isolation & purification; pharmacology; Parabens; chemistry; isolation & purification; pharmacology; Plant Extracts; chemistry; isolation & purification; pharmacology; Plant Leaves; chemistry; Plant Stems; chemistry; Polyalthia; chemistry; Vanillic Acid; chemistry; isolation & purification; pharmacology
- From: China Journal of Chinese Materia Medica 2011;36(8):1024-1027
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the chemical constituents of the branches and leaves of Polyalthia nemoralis.
METHODThe compounds were isolated and purified by silica gel, macroporous adsorption resin and Sephadex LH-20 column chromatographic methods. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data.
RESULTFourteen compounds were isolated and identified as syringic acid (1), 3-methoxy-4-hydroxycinnamic acid (2), vanillic acid (3), 4-hydroxybenzoic acid (4), mauritianin (5), (+)-xylopinidine (6), (+)-oblongine(7), (+)-tembetarine (8), eythritol (9), D-mannitol (10), ethyl-beta-D-glucopyranoside (11), (+)-magnoflorine (12), stepharanine (13), (2S, 4R)-4-hydroxy-2-piperidine-carboxylic acid (14), respectively.
CONCLUSIONAll the compounds were isolated from the genus Polyalthia for the first time; compounds 6 and 13 showed inhibitation activities against multi tumor cell lines.
