Effect of curcumin on expression of Abeta42 and Abeta-degrading enzyme NEP in APPswe/PS1dE9 double transgenic mice.
- Author:
Pengwen WANG
1
;
Hong WANG
;
Ruisheng LI
;
Yong LI
;
Ying REN
;
Zhihui ZHU
;
Haiyun SUN
;
Jinduo YANG
;
Jianning SUN
Author Information
- Publication Type:Journal Article
- MeSH: Amyloid beta-Peptides; drug effects; metabolism; Animals; CA1 Region, Hippocampal; drug effects; metabolism; Curcumin; pharmacology; DNA-Directed RNA Polymerases; drug effects; metabolism; Maze Learning; drug effects; Memory; drug effects; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments; drug effects; metabolism
- From: China Journal of Chinese Materia Medica 2011;36(8):1079-1082
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of curcumin on the expression of Abeta42 and its degrading enzyme NEP in APP/PS1 double transgenic mice.
METHOD3-month old APP/PS1 dtg mice were randomly divided into model group, positive control group and curcumin large, medium and small dose group. After 3 months, Morris water maze, immunohistochemistry, Western blot were applied to detect learning and memory ability of animal.
RESULTBehavior detection, compared with the model group, treatment group showed varying degrees of difference in place navigation test and space exploration experiments (P < 0.01 or P < 0.05). The expression of Abeta42 and its degrading enzyme NEP, Abeta42-positive cells of hippocampus CA1 region significantly increased in model mice as compared with normal control group (P < 0.01).
CONCLUSIONCurcumin can improve learning and memory ability of APP/PS1 double transgenic mice through increasing the expression of Abeta-degrading enzyme NEP and decreasing the expression of Abeta42.
