Chemical constituents of aerial parts of Gelsemium elegans.
- Author:
Qiuping ZHANG
1
;
Binfeng ZHANG
;
Guixin CHOU
;
Zhengtao WANG
Author Information
- Publication Type:Journal Article
- MeSH: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; chemistry; isolation & purification; Gelsemium; chemistry; Mass Spectrometry; Plant Components, Aerial; chemistry
- From: China Journal of Chinese Materia Medica 2011;36(10):1305-1310
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the chemical constituents from the aerial parts of Gelsemium elegans.
METHODCompounds were isolated and purified by repeated column chromatography, as well as semiprep arative HPLC, and their structures were identified by physicochemical properties and spectroscopic methods, such as NMR and MS.
RESULTSixteen compounds were obtained and identified from G. elegans, including nine alkaloids: koumine (1), gelsenicine (2), 19-(Z)-akuammidine (3), gelsemoxonine(4), gelsemin (5), gelsevirine (6), humantenine (7), 11-methoxygelsemamide (8) and gelegamine D (9). Three megastigmane glycosides: (3R, 5S, 6S, 7E, 9R)-megastigman-7-ene-3, 5, 6, 9-tetrol-9-O-beta-D-glucopyranoside (10), (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranoside] (11) and (6S, 7E, 9R) -6, 9-dihydroxy-4, 7-megastigmadien-3-one-9-O-[alpha-L-arabinopyranosyl-(1 --> 6) -beta-D-glucopyranoside] (12). Two flavone C-glycosides: orientin (13) and isorientin (14); one iridoid glycoside, sweroside (15) and one fructoside, n-butyl-alpha-D-fructofuranoside (16).
CONCLUSIONCompounds 10-16 were isolated from the genus Gelsemium for the first time.
