Mechanisms and effects of chinese herbal medicine delaying progression of chronic renal failure.
- Author:
Qing FENG
1
;
Yigang WAN
;
Chunming JIANG
;
Chaojun WANG
;
Qingxue WEI
;
Qing ZHAO
;
Jian YAO
Author Information
1. Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China. fred0504@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Kidney;
drug effects;
metabolism;
pathology;
Kidney Failure, Chronic;
drug therapy;
Transforming Growth Factor beta;
metabolism
- From:
China Journal of Chinese Materia Medica
2011;36(9):1122-1128
- CountryChina
- Language:Chinese
-
Abstract:
In this review,firstly,it has been discussed the mechanisms of Chinese herbal medicine ameliorating glomerulosclerosis and renal interstitial fibrosis during the progression of chronic renal failure (CRF) by improving glomerular hemodynamics turbulence, podocyte injury, transforming growth factor (TGF)-beta over-expression, hyperlipidemia, macrophage infiltration, tubular epithelial myofibroblast transdifferentiation, and nephrotoxicity of proteinuria. Secondly,it has been reported the clinical effects of Chinese herbal medicine improving renal function and some clinical complications in the patients with progressive CRF through various treatments including oral administration or coloclysis of Chinese herbal medicine, oral administration combined with coloclysis of Chinese herbal medicine, and colonic dialysis combined with coloclysis of Chinese herbal medicine. Finally,it has been reviewed the beneficial influences of Chinese herbal medicine on metabolic dysequilibrium of calcium and phosphonium, microinflammatory state, and uremic toxins in patients with uremia.
