Phenotypic modulation of corpus cavernous smooth musle cells and its influencing factors.
- Author:
Gang CHEN
1
;
Bo-dong LÜ
;
Xiao-jun HUANG
Author Information
1. Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang 310053, China. chengang0911@163.com
- Publication Type:Journal Article
- MeSH:
Cells, Cultured;
Humans;
Male;
Muscle, Smooth;
cytology;
Myocytes, Smooth Muscle;
classification;
cytology;
ultrastructure;
Penis;
Phenotype
- From:
National Journal of Andrology
2010;16(3):264-268
- CountryChina
- Language:Chinese
-
Abstract:
Corpus cavernous smooth muscle cells are the main functional component of the corpus cavernosum penis, whose phenotypic modulation is the key initial step in the proliferation and migration of smooth muscle cells. Therefore, an insight into the mechanism of the phenotypic modulation of smooth muscle cells and its influencing factors is important for the prevention and management of penis erectile dysfunction. Smooth muscle cells are generally divided into contracting (differentiated) and composing (undifferentiated, proliferated or dedifferentiated) types. It is found that TGF-beta, transcription factor E2F1, BTEB2 and insulin may affect the phenotypic modulation of smooth muscle cells. This paper presents an overview of the progress in the researches on the phenotypic modulation of corpus cavernous smooth muscle cells and its influencing factors.
