Epididymal cyst in von Hippel-Lindau syndrome: clinicopathologic analysis of 3 cases.
- Author:
Zhu HOU
1
;
Yong LUO
;
Yong-Guang JIANG
;
Jian-Feng SHANG
;
Dong CHEN
Author Information
- Publication Type:Case Reports
- MeSH: Actins; metabolism; Adult; Epididymis; pathology; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; metabolism; Male; Middle Aged; Spermatocele; etiology; metabolism; pathology; Vascular Endothelial Growth Factor A; metabolism; von Hippel-Lindau Disease; complications; metabolism; pathology
- From: National Journal of Andrology 2010;16(2):142-145
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathologic features of epididymal cyst in von Hippel-Lindau (VHL) syndrome.
METHODSWe reviewed the clinical data of 3 epididymal cyst patients treated by surgery, and detected the expressions of HIF-1alpha, VEGF, alpha-SMA and CD34 in the epididymal tissue samples by the immunohistochemistry SP method.
RESULTSAll the 3 patients underwent surgical removal of the epididymal cyst. Immunohistochemistry of the epididymal tissues showed HIF-1alpha, VEGF, alpha-SMA and CD34 to be positive. All the 3 cases were confirmed to be VHL syndrome, 1 right after surgery, and the other 2 within 8 years postoperatively.
CONCLUSIONEpididymal cyst is a usual benign disease, which may occur independently of or be complicated by VHL syndrome. If immunohistochemistry of epididymal tissues shows HIF-1alpha, VEGF, alpha-SMA and CD34 to be positive, VHL syndrome should be considered, and further clinical examinations and post-operation follow-up are necessitated.
