Improved experimental varicocele increases follicle-stimulating hormone and reduces inhibin B in rats.
- Author:
Ying-Chuan JIANG
1
;
Jian-Jun YU
;
Tao YAN
;
Yue-Min XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Follicle Stimulating Hormone; metabolism; Inhibins; metabolism; Male; Rats; Rats, Sprague-Dawley; Varicocele; metabolism
- From: National Journal of Andrology 2010;16(6):495-497
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of improved experimental left varicocele (ELV) on follicle-stimulating hormone (FSH) and inhibin B (InhB).
METHODSELV models were established by the improved method in 30 SD rats, and another 30 were included in a sham operation group as controls. Three months after the operation, the concentrations of the FSH and InhB were assayed by ELISA.
RESULTSThe concentration of FSH in the serum was significantly higher in the experimental group ([37.56 +/- 9.72] ng/ml) than in the control ([26.69 +/- 5.33] ng/ml) (P < 0.05), while that of InhB significantly lower in the former ([349.93 +/- 99.48] pg/ml) than in the latter ([768. 83 +/- 146.96] pg/ml) (P < 0.05).
CONCLUSIONImproved ELV can increase FSH and reduce InhB in rats, which may be associated with subfertility.
