The effect of angiotensin-(1-7) on the mRNA expression of PDGF and TGF-beta1 in the kidney of diabetic rats.
- Author:
Shuo-ping CHEN
1
;
Jing-chen ZHENG
;
Lian-Song NI
;
Guo-rong CHEN
;
Lei ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Angiotensin I; pharmacology; Animals; Diabetes Mellitus, Experimental; metabolism; Diabetic Nephropathies; metabolism; Kidney; metabolism; pathology; Male; Peptide Fragments; pharmacology; Platelet-Derived Growth Factor; genetics; metabolism; RNA, Messenger; genetics; metabolism; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; genetics; metabolism
- From: Chinese Journal of Applied Physiology 2008;24(4):475-478
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effect of angiotensin-(1-7) on the kidney of diabetic rats by observing the mRNA expression of PDGF and TGF-beta1.
METHODSSD rats were divided into three groups: Group C (uni-nephrectomy control group), Group D (diabetic model control group), Group T (Ang-(1-7) treated group). We evaluated blood glucose,urea nitrogen, creatinine and urine albumin excretion respectively, studied the renal morphology by light microscope, and detected the gene expression of PDGF, TGF-beta1 in renal tissue by RT-PCR technique.
RESULTSThere was significant difference between the group D and T about the RW/BW, renal morphology, the total urine protein and the mRNA expression of PDGF and TGF-beta1.
CONCLUSIONAng-(1-7) can relieve the renal process of diabetic rats.
