Effect and mechnaisim of GLU and GABA in OFC on gastric motility.
- Author:
Hui QIAO
1
;
Ting LIAN
;
Shao-li SONG
;
Shu-cheng AN
Author Information
- Publication Type:Journal Article
- MeSH: Amygdala; physiology; Animals; Female; Frontal Lobe; metabolism; physiology; Gastrointestinal Motility; drug effects; Glutamic Acid; pharmacology; Locus Coeruleus; physiology; Male; Random Allocation; Rats; Rats, Sprague-Dawley; gamma-Aminobutyric Acid; pharmacology
- From: Chinese Journal of Applied Physiology 2008;24(4):483-486
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo Investigate the effect of glutamate (Glu) and gamma-aminobutyric acid(GABA) in orbitofrontal cortex (OFC) on regulation of gastric motility.
METHODSUsing microinjection in OFC,together with lesion of related nucleus,and recording the intragastric pressure(IGP).
RESULTS(1) Microinjection of Glu in OFC caused a significant reduce of the amplitude of gastric motility, this effect could be reverse by lesion of amygdala, while lesion of LC had no influence on the effect of Glu. (2) microinjection of GABA in OFC could increase the amplitude of gastric motility significantly,and lesion of LC could abolish this effect,while lesion of amygdala could enhance the effect of GABA more.
CONCLUSIONMicroinjection of Glu in OFC may enhance the normal inhibitory effect of amygdale on gastric motility, and the effect of microinjection of GABA in OFC on gastric motility is closely related with LC.
